How should discrepancies in calculated volume during compounding be resolved?

Resolving discrepancies in calculated volume during compounding is critical to ensure the safety and efficacy of the final preparation. The correct approach is to recalculate and adjust the preparation accordingly. This method ensures that any errors in volume calculations are properly addressed, allowing the compounder to maintain the integrity of the formulation and the intended therapeutic effect. By recalibrating the volumes, the pharmacist can ensure that the dosage is accurate and complies with the prescribed standards, thus preventing potential adverse effects from over or under-dosing.

Disregarding the discrepancy would lead to potential inconsistencies in the final product and could result in harmful outcomes for the patient. Documenting only the original volume fails to provide an accurate record of the compounding process, which is vital for future reference and quality assurance. Consulting another pharmacist can be beneficial, but it does not directly address the immediate resolution of the volume discrepancy. The most effective practice is to recalculate and make the necessary adjustments to ensure that the compounded product meets all safety and quality standards.