What should be inspected to ensure proper sealing of a CSP?

Inspecting the closure for leakage or improper seal is crucial in ensuring the integrity of a Compounded Sterile Preparation (CSP). A proper seal is essential, as it protects the sterility of the compounded product, prevents contamination, and maintains the stability of the medication inside the container. If the seal is compromised or if there is leakage, the risk of microbial contamination increases significantly, which can lead to serious patient safety issues.

Additionally, an intact seal ensures that the formulation remains at the correct concentration, thus providing the intended therapeutic effect without degradation of the active ingredients. Therefore, evaluating the closure for any signs of leakage or failure directly impacts the overall quality and safety of the CSP. This inspection step is paramount in the overall quality assurance process within sterile compounding practices.